there are certainly many current "HANDGUNS" that are borderline, or obviously over sized, heavy to large and absurdly large!
if its to difficult to carry easily its almost certain you'll eventually leave it rather than carry it, especially if its a back-up to a rifle

now personally I find anything larger and heavier than the 7.5" barrel x frame SMITH AND WESSON 500 MAG,
to have exceeded that size and weight level, that's easily carried in a shoulder holster or chest holster rig.
my 445 dan wesson super mag has a longer 10" barrel but its a marginally smaller frame and lighter weight,
my N frame 10" S&W 44 mag is much easier to carry in a convenient shoulder holster.
(most people feel all those revolvers are to large for daily carry)(even when hunting)
and in my case I freely admit a 7.5"-8.375" barrel makes the revolver far easier to handle and carry.
I've handled and shot the ruger single action 480 revolvers, with a 6.5" barrel and find those rather easy to carry in a shoulder holster, but anything larger or heavier is a P.I.T.A. in my opinion to carry in a shoulder or chest holster and once you exceed about 6" in barrel length a belt holster rather rapidly becomes difficult to access with a back-pack or while seated in many cases.(besides yes its again just my opinion, )
those long cylinder rifle cartridge chambered handguns / single actions ( look like they belong in a cartoon) any cartridge longer than the 460 S&W requires a cylinder length that looks ODD in a handgun in my opinion
keep in mind you'll be carrying any handgun while hunting either in your hand or holstered and rapid easy access under all conditions is mandatory in a firearm you must depend on for defensive use.
yes I'm very well aware that some handguns like the 10" and longer barrel 460 S&W and 500 mag can be fitted with what is really a rifle sling, but at that size and weight your much better equipped if you carry a carbine of some type in my opinion, my sako 375 H&H or my BROWNING BLR in 450 marlin instantly comes to mind.
yes its personal preference but those long 10" or even a 7" barrel on those BFR single actions leave me cold!
now there's nothing walking in NORTH AMERICA a good shot with a 480 ruger 454 casull or similar 460-500 S&W revolver thats properly loaded and in skilled hands can't be easily killed with good shot placement.(in fact all of the large bears, elk, moose have all be repeatedly killed with 44 mag revolvers (yes marginal in some cases, but undeniable, that its been done repeatedly with heavy hard cast bullets, )
as they are effective at breaking, and penetrating large bone, like shoulders, spines and skulles and still reaching and lethally destroying the vitals organs, behind the mass of bone and hide and muscle!
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