generally the 375 will have a marginally flatter trajectory, vs the 416 having ,
a bit more "THUMP" or impact energy at close range
either caliber is more than adequate for anything walking in north America ,
if loaded with the correct ammo in the hands of a good shot
yeah my 340 wby and 375 H&H are damn effective and have really good extended reach,
if you're intending to shoot at over 150 yards or so, the 338, 375 & 416 caliber rifle's do have advantages
but after watching what my 45/70 and 450 marlin lever actions can do with various bullets,
on large game, Id have a hard time swapping to anything else if your talking about hunting bears at under,
100 yards or so. yes the 458 caliber bolt guns hit harder , but the increased recoil, and marginally slower,
to use bolt gun actions just don't seem to be that much more of an advantage in my experience,
as any of those rifles projectiles are devastating in the hands of a good shot, there's zero question ,
that a 458 win or 458 LOTT hits considerably harder , but the properly loaded 45/70 and 450 marlin,
have consistently had bullets exit big game.
keep in mind the vast majority of defensive use will be at under 30 yards, and a fairly fast second shot is almost mandatary
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